Some doors in science should stay shut. This is the story of the research that opened one — and the senator who refused to look away.
Start the story ↓Take a virus. Make it spread easier, infect more species, or hit harder — in a lab — so you can “study it.” That is gain-of-function research on potential pandemic pathogens.
Collected from bats, birds or animals.
Passed through cells or animals, or edited, until it gains new abilities.
Held behind biosafety levels that depend on people never failing.
One accident, one infected worker — and it is out in the world.
Supporters say it helps us predict and prepare for the next pandemic. Critics answer that you are creating the very thing you fear — a virus that does not exist in nature — and that history shows labs leak. In the author’s view the benefit does not justify the risk of a human-made pandemic.
The same skills that make a virus “more transmissible for research” are the skills needed to build a weapon. The 1972 Biological Weapons Convention bans bioweapons — but it has no inspection system, so nobody can verify what is happening inside a lab.
Research on pathogens, the response to pandemics and the rules about your own body are all run by the same small circle of institutions. Follow the thread to the Health pillar.
Go to the Health page →Scroll slowly. Each event builds toward the same question.
Imperial Japan runs a secret programme testing plague and other agents on prisoners — the dark origin of modern bioweapons research.
The US ends its offensive programme and the Biological Weapons Convention is signed. It has no way to check anyone.
Anthrax escapes from a Soviet military facility and kills dozens of people. The Soviet Union blamed bad meat for years; later it was admitted to be a lab accident. The Soviet programme (Biopreparat) kept running.
Anthrax sent through the US mail kills five people. The strain came from a US biodefence lab.
Scientists make bird flu (H5N1) transmissible between mammals. The world is alarmed; in 2014 the US pauses funding for the most dangerous gain-of-function work.
A new review framework lets the research resume under the oversight of the very agencies that fund it.
COVID-19 appears in the city that hosts the Wuhan Institute of Virology, a leading coronavirus lab. Where the virus came from is still disputed — a natural spill-over or a lab accident.
Senator Rand Paul confronts Dr Anthony Fauci in a Senate hearing over NIH funding that reached the Wuhan lab. The fight begins.
The administration restricts federally funded “dangerous gain-of-function” research, and Rand Paul’s committee investigation pushes on.
A physician and US Senator from Kentucky, Rand Paul has become the most persistent voice demanding that gain-of-function research be exposed and controlled.
In 2021 hearings Paul pressed Dr Fauci on whether NIH funded gain-of-function work in Wuhan. Fauci said the NIH had not funded such research as the NIH defines it; Paul said that definition was a way of dodging the question.
Paul sent referrals to the Department of Justice accusing Fauci of misleading Congress. Fauci has denied this. In January 2025 he received a full pre-emptive pardon from President Biden, which Paul called an admission of guilt.
As chairman of the Senate Homeland Security Committee from 2025, Paul has issued subpoenas and demanded records from federal agencies about the origin of COVID-19 and the funding of risky research.
Paul’s bill would create an independent board to approve life-sciences research that could create pandemic risk, instead of leaving the decision to the funding agencies. It is the legislative answer to the 2017 rules.
Part of Paul’s case is about grants: NIH money flowed to EcoHealth Alliance, which passed a subaward to the Wuhan Institute of Virology for bat-coronavirus research. EcoHealth and its president were later barred from federal funding.
Dr Anthony Fauci led the NIH’s infectious-disease institute (NIAID) for 38 years, and NIAID funded much of this research. Here is what the record and the arguments say.
In 2011 Fauci publicly argued that studying dangerous flu viruses was worth the risk to prepare for pandemics. Later he supported the 2017 resumption of the research.
NIAID funded coronavirus studies through EcoHealth Alliance, including work at the Wuhan lab. The NIH has said the work did not meet its own definition of gain of function. Critics say the definition was too narrow to be useful.
Early in 2020 Fauci and other scientists discussed the possibility of a lab origin, then publicly stressed natural origin. Several US agencies have since leaned toward a lab leak, with low to moderate confidence, while others favour a natural origin. No one has produced proof either way.
On 20 January 2025 Fauci was pardoned for any offences connected to his government service back to 2014. A pardon does not decide guilt or innocence, and it ends legal accountability, not public questions.
million+ COVID deaths officially reported worldwide
years Fauci led NIAID
routine inspectors under the Biological Weapons Convention
year the treaty was signed — with no way to verify it
Opinion and commentary based on public hearings, reporting and government statements. The origin of COVID-19 remains disputed, and Dr Fauci denies wrongdoing.
Who owns your medical record? Who decides which risks are acceptable? Keep reading on the Health page.
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